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| Antigenic Specificity | conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFkB is negatively modulated by the inhibitory proteins IkB. In turn IkB is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate IkB leading to its degradation and the resulting translocation of NFkB to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF- a, endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.Synonyms: Inhibitor of nuclear factor kappa-B kinase subunit alpha I-kappa-B kinase alpha IkBKA IKK-alpha IKK-A IkappaB kinase EC=2.7.11.10 |
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| Immunogen | IKK a peptide corresponding to the highly conserved of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH). |
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| Other Names | ikk|ikk1|ikka|ikkalpha|CHUK|IKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16|AI256658|Chuk1|Fbx24|Fbxo24|Ikka|zgc:56539 |
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| Gene, Accession # | Gene ID: 1147 |
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| Catalog # | ABIN100660 |
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| Price | |
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| Order / More Info | conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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