| 产品详情 |
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| Antigenic Specificity | conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB proteins . Most agents that activate NF-kappaB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkappaB . The key regulatory step in this pathway involves activation of a high molecular weight IkappaB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKalpha and IKKbeta serve as the catalytic subunits of the kinase and IKKgamma serves as the regulatory subunit . Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKbeta (Ser176 and Ser180 in IKKalpha), which causes conformational changes, resulting in kinase activation . Synonyms: CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, |
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| Immunogen | A synthetic peptide of human CHUK |
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| Other Names | ikk|ikk1|ikka|ikkalpha|CHUK|IKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16|AI256658|Chuk1|Fbx24|Fbxo24|Ikka|zgc:56539 |
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| Gene, Accession # | Gene ID: 1147 |
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| Catalog # | ABIN1683492 |
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| Price | |
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| Order / More Info | conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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