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| Antigenic Specificity | Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (pThr286) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ca2+/calmodulin-dependent protein kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to a wide variety of intercellular signals (Kennedy, 1998, Schulman and Hanson, 1993). CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+-homeostasis (Gleason et al., 2003, Soderling, 2000, Hudmon and Schulman, 2002). Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II (Meng et al., 2003, Picciotto et al., 1993). Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning (Elgersma et al., 2002). Anti-Phospho Thr286 CaM Kinase II Western blot of rat brain lysate showing specific immunolabeling of the ~50k (- and the ~60k (-CaM Kinase II phosphorylated at Thr286 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Anti-Thr286 CaM Kinase II. The immunolabeling is completely eliminated by treatment with (-Ptase. |
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| Immunogen | n/a |
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| Other Names | camk2|camk2b|zgc:112538|zgc:123320|CAMKA|CaMKII|R74975|mKIAA0968|PK2CDD|PKCCD |
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| Gene, Accession # | Gene ID: 12322,25400,550436,399284,374175,100172212,815,612941,530719,100341507 |
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| Catalog # | ABIN361458 |
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| Price | |
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| Order / More Info | Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (pThr286) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 21236297, 21276808, 22918957, 22615928, 22593045, 12045104, 9651538, 8253780, 8385278, 10851169, 12408851, 24843070, 24780380, 17855343, 20353941, 20424167, 12563265 |
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