| 产品详情 |
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| Antigenic Specificity | FZR1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. This FZR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human FZR1. |
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| Immunogen | Human FZR1. |
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| Other Names | Fzr; CDC20-like protein 1; hCDH1; Cdh1/Hct1 homolog; CDH1; FYR; KIAA1242; FZR1; FZR2; HCDH; CDC20C; Fizzy-related protein homolog |
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| Gene, Accession # | FZR1, SwissProt: Q9UM11 |
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| Catalog # | abx030710 |
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| Price | |
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| Order / More Info | FZR1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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| 产品资料 |
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