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| Product Name | Galeterone |
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| Description | Purity >98%. The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17Alpha-hydroxylase/17,20 lyase because it catalyzes both 17Alpha-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC50 = 300 nM) that has been shown to competitively block synthetic androgen binding (EC50 = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays. Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC50 value of 2.9 µM and demonstrates synergy with everolimus or gefitinib for growth inhibition. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 17-(1H-benzimidazol-1-yl)-androsta-5,16-dien-3Beta-ol, TOK-001 |
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| Gene, Accession, CAS # | CAS: 851983-85-2 |
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| Catalog # | LS-H7887 |
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| Order / More Info | Galeterone from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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