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| Product Name | GSK3Beta Inhibitor VIII |
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| Description | Purity >98%. GSK3Beta Inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3Beta (Ki = 38 nM; IC50 = 104 nM). It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Ki s = > 100 µM). GSK3Beta Inhibitor VIII demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 µM) at a GSK3-specific site (Ser396 ) in cells stably expressing human four-repeat tau protein and also by protecting Beta-amyloid-exposed N2A neuroblastoma cells against cell death. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-urea, AR 0133418, AR 014418, Glycogen Synthase Kinase 3-Beta Inhibitor VIII, SN 4521 |
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| Gene, Accession, CAS # | CAS: 487021-52-3 |
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| Catalog # | LS-H8013 |
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| Price | |
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| Order / More Info | GSK3Beta Inhibitor VIII from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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