| 产品详情 |
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| Product Name | GSK-3Beta Inhibitor II |
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| Description | Purity >95%. GSK3Beta Inhibitor II is a potent inhibitor of glycogen synthase kinase-3Beta (GSK3Beta; IC50 = 390 nM) that does not inhibit GSK-3Alpha. Also referred to as tip-oxadiazole, this compound blocks the functional regulation of p53 by GSK3Beta, decreasing levels of MDM2, p21, and Bax and modulating mitochondrial p53 apoptotic signaling. GSK3Beta Inhibitor II also blocks GSK3Beta-mediated Tau phosphorylation and ABeta25-35 -induced memory impairment in mouse hippocampus. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[5-[[(3-iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]-pyridine, Glycogen Synthase Kinase 3-Beta Inhibitor II, Tip-oxadiazole |
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| Gene, Accession, CAS # | CAS: 478482-75-6 |
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| Catalog # | LS-H8012 |
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| Order / More Info | GSK-3Beta Inhibitor II from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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