产品名称 Rab5/RAB5A Antibody from BOSTER BIO
产品货号 M01891-1
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BOSTER BIO
产品概述
产品详情
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Antigenic SpecificityRab5/RAB5A
Clone3E9
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG2b
Formatunconjugated
Size100ug
Concentration0.5-1mg/ml, actual concentration varies by lot.
ApplicationsFlow Cytometry, WB
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionMouse IgG monoclonal Picoband™ antibody for Rab5/RAB5A detection. Tested with Tested with WB, FCM in Human;Mouse;Rat. No cross reactivity with other proteins. RAB5A (Ras-associated protein RAB5A), also called RAB5, is a protein that in humans is encoded by the RAB5A gene. RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. The RAB5A gene is mapped on 3p24.3. RAB5 is indispensable for a form of receptor tyrosine kinase-induced actin remodeling called circular ruffling.?It signals to the actin cytoskeleton through RNTRE, a RAB5-specific GTPase-activating protein (GAP).?RAB5 activity on phagosome membranes began to increase on disassembly of the actin coat encapsulating phagosomes. In addition, RAB5 activation is either continuous or repetitive for up to 10 minutes, but it ends before the collapse of engulfed apoptotic cells. Expression of a dominant-negative mutant of RAB5 delayed this collapse of apoptotic thymocytes, showing a role for RAB5 in phagosome maturation.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human Rab5 (179-215aa KKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN), different from the related mouse and rat sequences by three amino acids.
Other NamesRas-related protein Rab-5A; RAB5A; RAB5
Gene, Accession #RAB5A, UniProt: P20339
Catalog #M01891-1
Price
Order / More InfoRab5/RAB5A Antibody from BOSTER BIO
Product Specific Referencesn/a
产品资料