| 产品详情 |
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| Product Name | Kartogenin |
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| Description | Purity >98%. Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor Beta subunit (CBFBeta). When dissociated from filamin A, CBFBeta translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-benzoic acid |
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| Gene, Accession, CAS # | CAS: 4727-31-5 |
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| Catalog # | LS-H8325 |
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| Order / More Info | Kartogenin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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