| 产品详情 |
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| Antigenic Specificity | Human AIM2 |
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| Clone | 23059 |
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| Host Species | Rabbit |
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| Reactive Species | human, monkey |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human AIM2 monoclonal antibdoy for WB, IP. Absent in melanoma 2 (AIM2) is an interferon-inducible protein containing an amino-terminal pyrin domain and carboxy-terminal HIN-200 domain that functions in innate immunity and tumor progression. Expression of AIM2 can inhibit cell growth and tumor formation. Furthermore, the AIM2 gene has a high frequency of mutations associated with microsatellite-unstable colorectal cancers. AIM2 has a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18. Caspase-1 activation is regulated by multi-protein complexes referred to as inflammasomes. Distinct inflammasome complexes have been described containing NLRP1/NALP1, NLRP3/NALP3, IPAF, and AIM2. The HIN-200 domain of AIM2 is responsible for binding to cytoplasmic double stranded DNA, resulting in caspase-1 activation. This inflammasome complex also involves binding of the pyrin domain of AIM2 to the CARD-domain protein ASC/TMS1, which then interacts directly with caspase-1. As a result, AIM2 has been demonstrated to be an important sensor for a number of different pathogens. |
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| Immunogen | Synthetic peptide |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 9447, UniProt: O14862 |
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| Catalog # | CABT-L1905 |
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| Price | |
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| Order / More Info | Human AIM2 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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