| 产品详情 |
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| Product Name | Palosuran |
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| Description | An antagonist of UTR (IC50s = 3.6 and 1,475 nM for CHO cell membranes expressing human and rat recombinant receptors, respectively); inhibits urotensin II-induced contraction of isolated rat aortic rings in a concentration-dependent manner; reduces plasma endothelin-1, urotensin II, and TGF-β1 levels, as well the main pulmonary arterial pressure and right ventricular hypertrophy index in a monocrotaline-induced rat model of PAH at 300 mg/kg twice per day; reduces serum glucose, cholesterol, and triglyceride levels and increases survival in an STZ-induced rat model of diabetes at 300 mg/kg per day; decreases albuminuria and global kidney lesion scores in STZ-induced diabetic rats |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ?ACT058362 |
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| Gene, Accession, CAS # | CAS: 540769-28-6 |
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| Catalog # | 23460-1 |
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| Order / More Info | Palosuran from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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