| 产品详情 |
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| Antigenic Specificity | CD180 Molecule (CD180) |
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| Clone | G28-8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Functional Studies (Func),Immunoprecipitation (IP),Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. |
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| Immunogen | Human tonsillar B cells |
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| Other Names | Ly78|CD180|LY64|RP105|F630107B15 |
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| Gene, Accession # | Gene ID: 4064 |
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| Catalog # | ABIN559680 |
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| Price | |
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| Order / More Info | CD180 Molecule (CD180) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2480376, 3259604, 12794135, 11709456, 17470533, 12714520 |
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