| 产品详情 |
| Edit |   |
|---|
| Product Name | Apoptozole |
|---|
| Description | Purity >98%. Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity. It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells. Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-[[2-[3,5-bis (trifluoromethyl)phenyl]-4,5-bis (4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide, Apoptosis Activator VII |
|---|
| Gene, Accession, CAS # | CAS: 1054543-47-3 |
|---|
| Catalog # | LS-H6573 |
|---|
| Price | |
|---|
| Order / More Info | Apoptozole from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|