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| Antigenic Specificity | Superoxide Dismutase 3, Extracellular (SOD3) (aa 227-236) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunofluorescence (IF),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2Eo/oo to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (6). SOD3 can also be distinguished by its heparin-binding capacity (1).Cellular Localization: Extracellular Space- 99% is anchored in the tissue interstitium | 1% is located in the vasculature in between the plasma and the endothelium |
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| Immunogen | Peptide corresponding to AA 227-236 of human EC SOD |
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| Other Names | SOD3|LOC780439|fb05f10|si:dkey-117m1.6|sod3|wu:fb05f10|EC-SOD|AI314465|ECSODPT|ECSOD|SODA.4 |
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| Gene, Accession # | Gene ID: 6649,20657,25352 |
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| Catalog # | ABIN1686654 |
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| Price | |
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| Order / More Info | Superoxide Dismutase 3, Extracellular (SOD3) (aa 227-236) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 1477980, 3315461, 12736188, 2855738, 2462451 |
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