| 产品详情 |
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| Product Name | 6-Thioguanine |
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| Description | Purity >96% by HPLC, NMR. 6-Thioguanine is a methyltransferase inhibitor. After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1). Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity. Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model. Anticancer and immunosuppressive activity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Amino-6-mercaptopurine |
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| Gene, Accession, CAS # | CAS: 154-42-7 |
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| Catalog # | LS-H14573 |
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| Order / More Info | 6-Thioguanine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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