| 产品详情 |
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| Antigenic Specificity | ADRBK1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Beta-adrenergic receptor kinase (ADRBK1), also known as GRK2, phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. This ADRBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human ADRBK1. |
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| Immunogen | Human ADRBK1. |
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| Other Names | ADRBK1; BARK; BARK1; GRK2; Beta-adrenergic receptor kinase 1; G-protein coupled receptor kinase 2; Adrenergic Receptor Beta Kinase 1; BETA-ARK1; FLJ16718 |
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| Gene, Accession # | Accession: NP_001610.2, SwissProt: P25098 |
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| Catalog # | abx033109 |
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| Price | |
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| Order / More Info | ADRBK1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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