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| Product Name | Smac, CT, Blocking Peptide |
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| Description | The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identi?ed and designated Smac/DIABLO (1,2). Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases (3-6). Smac/DIABLO is expressed in a variety of human and mouse tissues (1,2). Peptide (SDEGADQEEEAYLRED) corresponding to amino acids 222 to 237 of murine Smac/DIABLO (2). Applications: Suitable for use in ELISA and Western Blot. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | Smac, CT, Blocking Peptide (DIABLO, Direct IAP Binding Protein of Low Pi, Second Mitochondrial Activator of Cell Death) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | S1014-49P |
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| Price | |
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| Order / More Info | Smac, CT, Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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