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| Product Name | Human 41BBL protein |
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| Description | 4-1BB Ligand Human Recombinant protein. 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin. Purity > 95.0% as determined by SDS-PAGE. |
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| Size | 5 ug, 20 ug |
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| Concentration | Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4. |
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| Applications | SDS-PAGE |
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| Other Names | CD137L protein, CD137-L protein, 4-1BBL protein, 4-1BB Ligand protein, TNFSF9 protein, Tumor Necrosis Factor (ligand) Superfamily Member 9. |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | orb167830 |
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| Price | |
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| Order / More Info | Human 41BBL protein from BIORBYT LTD. |
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| Product Specific References | n/a |
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