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| Product Name | 4-Methylumbelliferyl-Alpha-L-Iduronide (free acid) |
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| Description | Purity >98%. 4-Methylumbelliferyl-Alpha-L-iduronide (free acid) is a fluorogenic substrate for Alpha-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-Alpha-L-iduronide is cleaved by Alpha-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of Alpha-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-methyl-2-oxo-2H-1-benzopyran-7-yl a-L-idopyranosiduronic acid, 4-Methylumbelliferyl-Alpha-L-Idopyranosiduronic Acid, 4-MU-Alpha-IdoA, MU-Alpha-IdoA |
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| Gene, Accession, CAS # | CAS: 66966-09-4 |
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| Catalog # | LS-H6141 |
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| Order / More Info | 4-Methylumbelliferyl-Alpha-L-Iduronide (free acid) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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