| 产品详情 |
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| Product Name | BMS-833923 |
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| Description | Purity >98% by HPLC. BMS-833923 is a potent inhibitor of Smo (Smoothened) with potential antineoplastic activity. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS-833923 inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid, XL-139 |
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| Gene, Accession, CAS # | CAS: 1059734-66-5 |
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| Catalog # | LS-H3578 |
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| Order / More Info | BMS-833923 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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