| 产品详情 |
| Edit |   |
|---|
| Product Name | BMS-777607 |
|---|
| Description | Purity >98%. BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively. At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50 s = 14, 16, 78, 120, and 180 nM, respectively). In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis. In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide, BMS-817378 |
|---|
| Gene, Accession, CAS # | CAS: 1025720-94-8 |
|---|
| Catalog # | LS-H6863 |
|---|
| Price | |
|---|
| Order / More Info | BMS-777607 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|