| 产品详情 |
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| Antigenic Specificity | Integrin beta 1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, canine, equine, chicken, human, mouse, porcine, rat, sheep |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 100 ug, 200 ug |
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| Concentration | n/a |
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| Applications | ICC, IF, IHC-P, P-ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal antibody to IB1 also known as VLA4, which is expressed in the differentiated prostate gland cells as well as in the placenta but is highly expressed on the surface of erythroleukemia cells and hematopoietic cell lines. It is found in the recycling endosome. Integrin extensively regulates cell adhesion and laminin matrix deposition. It is also Involved in promoting endothelial cell motility and angiogenesis along with osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. This protein may also be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1 it serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase required for the successful completion of cytokinesis. They provide a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion and formation of invadopodia and matrix degradation processes, promoting cell invasion. |
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| Immunogen | KLH conjugated synthetic peptide derived from human Integrin beta 1. |
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| Other Names | beta1 integrin, CD29, Fibronectin receptor subunit beta, FNRB, Glycoprotein IIa, GP IIa, GPIIA, Integrin beta-1, integrin VLA-4 beta subunit, Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), ITB1_HUMAN, ITGB1, MDF2, MSK12, OTTHUMP00000019420, Very late activation protein, beta polypeptide, VLA BETA, VLA-4 subunit beta, VLA-BETA, VLAB, VLAbeta |
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| Gene, Accession # | Gene ID: 3688, UniProt: P05556 (Human); P09055 (Mouse); P49134 (Rat) |
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| Catalog # | orb251610 |
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| Price | |
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| Order / More Info | Integrin beta 1 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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