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| Product Name | Cylindromatosis (Turban Tumor Syndrome) (CYLD) (Isoform 1) protein (His tag) |
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| Description | Ubiquitin carboxyl-terminal hydrolase CYLD is a 956 amino acid (aa) member of the peptidase C67 protein family with a predicted molecular weight of 107 kDa. The mouse and rat CYLD orthologs share 95% and 94% aa sequence identity with the human protein, respectively. Two isoforms of CYLD have been identified, a full-length isoform and a second isoform that lacks aa 305-307 due to alternative splicing. Expression of CYLD has been reported in fetal brain as well as adult brain, heart, leukocytes, skeletal muscle, spleen and testis. CYLD acts as a deubiquitinase and removes K63-linked ubiquitin chains from multiple substrates including IkappaB, c-Jun, and c-Fos, resulting in the inhibition of NF-kappaB and JNK signaling. In some contexts, CYLD enhances mitosis entry and it has also been shown to delay G1/S phase entry suggesting that CYLD regulates multiple phases of the cell cycle. CYLD is recognized as a tumor suppressor and mutations in CYLD result in skin appendage syndromes including Brooke-Spiegle Syndrome, familial cylindromatosis and familial trichoepitheliomas type 1. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | cyld|2010013M14Rik|2900009M21Rik|C130039D01Rik|CDMT|CYLD1|EAC|mKIAA0849|LRRGT00003|Rp1|Rp1h|BRSS|CYLDI|MFT|MFT1|SBS|TEM|USPL2 |
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| Gene, Accession, CAS # | Gene ID: 1540 |
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| Catalog # | ABIN2745631 |
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| Order / More Info | Cylindromatosis (Turban Tumor Syndrome) (CYLD) (Isoform 1) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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