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| Product Name | SCF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40kD type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189aa extracellular domain (ECD), a 23aa transmembrane segment, and a 36aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25kD soluble molecule which is comparable to the only formproduced by Steel-dickie mutant mice. An alternatively spliced isoform of human SCF exists that lacks 28aa that encompass the primary proteolytic recognition site. Within the ECD of the long isoform (correspo |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG) |
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| Gene, Accession, CAS # | SwissProt: P21583 |
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| Catalog # | S7973-01A |
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| Price | |
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| Order / More Info | SCF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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