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| Antigenic Specificity | Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) |
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| Clone | 3F8 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2b |
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| Format | unconjugated |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ELISA,Flow Cytometry (FACS),Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059. |
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| Immunogen | Purified recombinant fragment of human MAPK expressed in E. Coli. |
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| Other Names | erk1/2 |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN1724731 |
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| Order / More Info | Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 19833733 |
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