产品名称 Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) protein (His tag) from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1691492
产品价格 现货询价,电话:010-67529703
产品规格 1 mg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
Edit&nbsp
Product NameMesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) protein (His tag)
DescriptionMesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.Alternative Names: Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, ARMET, ARP
Size1 mg
Concentrationn/a
Applicationsn/a
Other NamesMANF|ARMET|ARP-like|CG7013|DmMANF|Dmel\\CG7013|anon-EST:ParkEST188|arp|armet|im:6909481|zgc:153327|ARP|3230402M22Rik|AA407711|AA408789|AA673178|Armet|D17914|D18Mgi17|RBM15B
Gene, Accession, CAS #Gene ID: 7873
Catalog #ABIN1691492
Price
Order / More InfoMesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) protein (His tag) from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
产品资料