| 产品详情 |
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| Product Name | Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) protein |
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| Description | Recombinant Human Cyclin-Dependent Kinase 2/CDK2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Leu298) of Human CDK2 fused with a His tag at the N-terminus. Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MGC84068|cinp|CINP|p33(CDK2)|A630093N05Rik|wu:fa10c02|zgc:56598|zgc:77684|eg1|CDKN2|cdk2L |
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| Gene, Accession, CAS # | Gene ID: 1017 |
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| Catalog # | ABIN1690952 |
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| Order / More Info | Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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