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| Product Name | Pregnenolone Carbonitrile |
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| Description | Purity >98%. Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7Alpha-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion. Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3Beta-hydroxy-20-oxo-pregn-5-ene-16a-carbonitrile, PCN, Pregnenolone 16Alpha-carbonitrile, SC-4674 |
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| Gene, Accession, CAS # | CAS: 1434-54-4 |
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| Catalog # | LS-H9500 |
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| Order / More Info | Pregnenolone Carbonitrile from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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