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| Product Name | NKIRAS1, 1-192aa, Human, His tag, E.coli |
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| Description | Purity: > 95% by SDS - PAGE Format: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT. NKIRAS1, also known as NF-kappa-B inhibitor-interacting Ras-like protein 1, belongs to the small GTPase superfamily. NKIRAS1 is atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. It may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Recombinant human NKIRAS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
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| Size | 50ug, 10ug, |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | NF-kappa-B inhibitor-interacting Ras-like protein 1, kappaB-Ras1, KBRAS1 |
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| Gene, Accession, CAS # | NP 065078 |
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| Catalog # | ATGP1412 |
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| Order / More Info | NKIRAS1, 1-192aa, Human, His tag, E.coli from ATGen |
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| Product Specific References | n/a |
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