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| Antigenic Specificity | HDAC4/5/9 (pS246/259/220) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HDAC4/5/9 (pS246/259/220) Antibody is a Rabbit Polyclonal antibody against HDAC4/5/9 (pS246/259/220). Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents. |
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| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S246/259/220 of human HDAC4/5/9. |
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| Other Names | HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A/HD5; NY-CO-9/HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL |
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| Gene, Accession # | HDAC4, HDAC5, HDAC9, Gene ID: 9759/10014/9734, SwissProt: P56524, Q9UQL6, Q9UKV0 |
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| Catalog # | abx000331 |
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| Price | |
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| Order / More Info | HDAC4/5/9 (pS246/259/220) Antibody from ABBEXA |
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| Product Specific References | n/a |
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