产品名称 Recombinant Human Hypoxia-inducible factor 1-alpha (HIF1A), partial from BIOMATIK
产品货号 RPC24289
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
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Product NameRecombinant Human Hypoxia-inducible factor 1-alpha (HIF1A), partial
DescriptionPurity > 90% as determined by SDS-PAGE. MW: 31kDa. Partial: 579-826aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in bryonic vascularization, tumor angiogenesis and pathophysiology of ischic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response elent (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX ses to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia
Size100ug
Concentrationn/a
ApplicationsRUO
Other NamesARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1Class E basic helix-loop-helix protein 78; bHLHe78Member of PAS protein 1; PAS domain-containing protein 8
Gene, Accession, CAS #HIF1A, UniProt: Q16665
Catalog #RPC24289
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Order / More InfoRecombinant Human Hypoxia-inducible factor 1-alpha (HIF1A), partial from BIOMATIK
Product Specific Referencesn/a
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