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| Product Name | Recombinant Human 5-hydroxytryptamine receptor 2B (HTR2B) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 70.3kDa. Full Length: 1-481aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Serotonin receptor 2B |
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| Gene, Accession, CAS # | HTR2B, UniProt: P41595 |
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| Catalog # | RPC20736 |
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| Order / More Info | Recombinant Human 5-hydroxytryptamine receptor 2B (HTR2B) from BIOMATIK |
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| Product Specific References | n/a |
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