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| Product Name | HA-14-1 |
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| Description | Purity >98%. HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3. It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W. HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (aR,4R)-rel -2-amino-6-bromo-a-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester |
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| Gene, Accession, CAS # | CAS: 65673-63-4 |
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| Catalog # | LS-H8069 |
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| Price | |
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| Order / More Info | HA-14-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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