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| Product Name | Ubiquitin-Conjugating Enzyme E2, J1, U (UBE2J1) protein (His tag) |
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| Description | Ubiquitin-conjugating Enzyme E2, J1 (UBE2J1), also known as HsUbc6e, is a 318 amino acid (aa) member of the ubiquitin-conjugating (E2) enzyme family with a predicted molecular weight of approximately 35 kDa. The human protein shares 92% and 85% aa sequence identity with the mouse and rat orthologs, respectively. UBE2J1 has an E2 catalytic core domain with an active site cysteine residue that is required for the formation of a thioester bond with ubiquitin. It localizes to endoplasmic reticulum (ER) membranes where it participates in ER-associated degradation (ERAD) of misfolded proteins. In response to ER stress, UBE2J1 is phosphorylated on Ser184 in a PERK-dependent manner. It has also been shown to function with the HRD1 ubiquitin ligase (E3) to promote the ubiquitination and degradation of misfolded MHC class I heavy chain via ERAD. Additionally, UBE2J1 may have a preventative role in early-onset systemic amyloidosis. It has a redundant role, along with the UBE2G2 E2 enzyme, in promoting the degradation of a mutant form of transthyretin that is associated with this disease. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | NCUBE1|ubc6p|cgi-76|ncube1|hspc153|hspc205|hsu93243|HSPC153|HSPC205|HSU93243|NCUBE-1|UBC6|Ubc6p|zgc:63554|UB2J1|0710008M05Rik|1110030I22Rik|Ncube|Ncube1 |
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| Gene, Accession, CAS # | Gene ID: 51465 |
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| Catalog # | ABIN2745932 |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2, J1, U (UBE2J1) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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