| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human Insulin-like growth factor I (IGF1) |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 9.7kDa. Full Length of Mature Protein: 49-118aa. N-terminal 6xHis-tagged. Homo sapiens (Human). The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Mechano growth factor |
|---|
| Gene, Accession, CAS # | IGF-1, UniProt: P05019 |
|---|
| Catalog # | RPC25227 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human Insulin-like growth factor I (IGF1) from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|