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| Product Name | Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx (vpx) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 17.2kDa. Full Length: 1-113aa. N-terminal 6xHis-tagged. Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2). Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Viral protein XX ORF protein |
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| Gene, Accession, CAS # | vpx, UniProt: P18099 |
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| Catalog # | RPC22487 |
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| Price | |
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| Order / More Info | Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx (vpx) from BIOMATIK |
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| Product Specific References | n/a |
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