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| Product Name | Recombinant Rat Ephrin-A1 (Efna1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 23.4kDa. Full Length of Mature Protein: 18-182aa. N-terminal 6xHis-tagged. Rattus norvegicus (Rat). Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | EPH-related receptor tyrosine kinase ligand 1; LERK-1Immediate early response protein B61 |
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| Gene, Accession, CAS # | Efna1, UniProt: P97553 |
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| Catalog # | RPC21243 |
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| Order / More Info | Recombinant Rat Ephrin-A1 (Efna1) from BIOMATIK |
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| Product Specific References | n/a |
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