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| Product Name | Recombinant Rat C-X-C motif chemokine 2 protein (Cxcl2) (Active) |
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| Description | Purity > 80% as determined by SDS-PAGE. MW: 57.3kDa. Extracellular Domain: 20-291aa. C-terminal FC-tagged. Homo sapiens (Human). CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | B-Lymphocyte Antigen CD19; B-Lymphocyte Surface Antigen B4; Differentiation Antigen CD19; T-Cell Surface Antigen Leu-12; CD19 |
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| Gene, Accession, CAS # | CD19, UniProt: P15391 |
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| Catalog # | RPC26952 |
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| Order / More Info | Recombinant Rat C-X-C motif chemokine 2 protein (Cxcl2) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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