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| Product Name | Recombinant Human Transmembrane protease serine 2 (TMPRSS2), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 44.8kDa. Extracellular Domain: 106-492aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Serine protease 10 |
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| Gene, Accession, CAS # | TMPRSS2, UniProt: O15393 |
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| Catalog # | RPC24995 |
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| Order / More Info | Recombinant Human Transmembrane protease serine 2 (TMPRSS2), partial from BIOMATIK |
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| Product Specific References | n/a |
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