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| Product Name | Recombinant Human Transient receptor potential cation channel subfamily A member 1 (TRPA1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 35.2kDa. Partial: 957-1119aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro) (PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta (9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120 |
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| Gene, Accession, CAS # | TRPA1, UniProt: O75762 |
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| Catalog # | RPC22177 |
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| Price | |
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| Order / More Info | Recombinant Human Transient receptor potential cation channel subfamily A member 1 (TRPA1), partial from BIOMATIK |
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| Product Specific References | n/a |
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