| 产品详情 |
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| Antigenic Specificity | Death-Domain Associated Protein (DAXX) |
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| Clone | 7A11 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein G purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ELISA,Flow Cytometry (FACS),Immunocytochemistry (ICC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. |
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| Immunogen | Purified recombinant fragment of human DAXX expressed in E. coli. |
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| Other Names | im:6905684|LOC100226911|BING2|DAP6|EAP1 |
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| Gene, Accession # | Gene ID: 1616 |
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| Catalog # | ABIN969493 |
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| Price | |
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| Order / More Info | Death-Domain Associated Protein (DAXX) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 15302935, 9455907 |
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