| 产品详情 |
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| Product Name | iCRT5 |
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| Description | Purity >98% by NMR, TLC. iCRT5 is a selective CRT (b-catenin-responsive transcription) inhibitor. IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the b-catenin, TCF4 interaction. Displays poor inhibition of cell proliferation in triple-negative breast cancer cells. Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs. Modulators of Wnt signaling show great promise in animal models of several cancers. Cell permeable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid |
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| Gene, Accession, CAS # | CAS: 18623-44-4 |
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| Catalog # | LS-H14708 |
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| Price | |
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| Order / More Info | iCRT5 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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