产品名称 Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) from BIOMATIK
产品货号 RPC23477
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
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Product NameRecombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6)
DescriptionPurity > 90% as determined by SDS-PAGE. MW: 66kDa. Full Length of Mature Protein: 2-355aa. N-terminal GST-tagged. Homo sapiens (Human). NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.
Size100ug
Concentrationn/a
ApplicationsRUO
Other NamesRegulatory protein SIR2 homolog 6; SIR2-like protein 6
Gene, Accession, CAS #SIRT6, UniProt: Q8N6T7
Catalog #RPC23477
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Order / More InfoRecombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) from BIOMATIK
Product Specific Referencesn/a
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