产品名称 Recombinant Human G1/S-specific cyclin-D3 (CCND3) from BIOMATIK
产品货号 RPC21047
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
产品概述
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Product NameRecombinant Human G1/S-specific cyclin-D3 (CCND3)
DescriptionPurity > 90% as determined by SDS-PAGE. MW: 59.5kDa. Full Length: 1-292aa. N-terminal GST-tagged. Homo sapiens (Human). Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Size100ug
Concentrationn/a
ApplicationsRUO
Other Namesn/a
Gene, Accession, CAS #CCND3, UniProt: P30281
Catalog #RPC21047
Price
Order / More InfoRecombinant Human G1/S-specific cyclin-D3 (CCND3) from BIOMATIK
Product Specific Referencesn/a
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