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Product Name | Recombinant Human G1/S-specific cyclin-D3 (CCND3) |
Description | Purity > 90% as determined by SDS-PAGE. MW: 59.5kDa. Full Length: 1-292aa. N-terminal GST-tagged. Homo sapiens (Human). Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
Size | 100ug |
Concentration | n/a |
Applications | RUO |
Other Names | n/a |
Gene, Accession, CAS # | CCND3, UniProt: P30281 |
Catalog # | RPC21047 |
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Order / More Info | Recombinant Human G1/S-specific cyclin-D3 (CCND3) from BIOMATIK |
Product Specific References | n/a |
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