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| Product Name | BCL2-Associated Athanogene 3 (BAG3) (AA 1-575) protein (His tag) |
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| Description | BAG3 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity. BAG proteins participate with Hip for their binding to Hsc70/Hsp70 ATPase domain and encourage substrate release. BAG proteins have about 45 AA BAG domain close to the C terminus however they differ noticeably in their N-terminal regions. BAG3 includes a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact particularly with the Hsc70 ATPase domain in vitro and in mammalian cells. They bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. BAG3 plays a role as a protein-refolding cochaperone of the bcl2 binding protein BAG family and as upregulated in response to persistent stress of cellular calcium balance dysregulation. BAG3 has been shown to diminish stress-induced apoptosis Synonyms: BIS, CAIR-1, BAG-3, BAG Family Molecular Chaperone Regulator 3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1, BAG3, MGC104307 |
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| Size | 2 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | bag3-A|MGC53113|zgc:100859|BAG3|ATBAG3|BCL-2-associated athanogene 3|T28J14.160|T28J14_160|BAG-3|BIS|CAIR-1|MFM6|AA407278|Bis|mg638 |
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| Gene, Accession, CAS # | Gene ID: 9531 |
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| Catalog # | ABIN807653 |
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| Order / More Info | BCL2-Associated Athanogene 3 (BAG3) (AA 1-575) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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