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| Product Name | PLD Inhibitor, FIPI (Compound 4k, PLD Inhibitor I) |
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| Description | Purity ~99% (HPLC). A cell-permeable, PLD1/2 inhibitor (IC50=1nM and 10nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50=20nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic b-cells. Formula: C23H24FN5O2 Molecular Weight: 421.2 Solubility: DMSO (100mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217677 |
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| Order / More Info | PLD Inhibitor, FIPI (Compound 4k, PLD Inhibitor I) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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