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Product Name | Recombinant Escherichia coli RNA-splicing ligase RtcB (rtcB) |
Description | Purity > 90% as determined by SDS-PAGE. MW: 61.2kDa. Full Length: 1-408aa. N-terminal 6xHis-SUMO-tagged. Escherichia coli (strain K12). RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases |
Size | 100ug |
Concentration | n/a |
Applications | RUO |
Other Names | n/a |
Gene, Accession, CAS # | rtcB, UniProt: P46850 |
Catalog # | RPC22607 |
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Order / More Info | Recombinant Escherichia coli RNA-splicing ligase RtcB (rtcB) from BIOMATIK |
Product Specific References | n/a |
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