| 产品详情 |
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| Product Name | DBZ |
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| Description | Purity >98%. Gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (ABeta), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer's disease. DBZ is a dipeptidic inhibitor of Gamma-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 µM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of ABeta40 by reducing ABeta40 levels by 71%. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide, Dibenzazepine, YO-01027 |
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| Gene, Accession, CAS # | CAS: 209984-56-5 |
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| Catalog # | LS-H7378 |
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| Price | |
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| Order / More Info | DBZ from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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