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| Product Name | Caspase 12, IN, Blocking Peptide |
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| Description | Purified 60-70%. Peptide (CTPSSPSESKRKVEDDE) corresponding to aa100-116 of murine caspase-12(3). Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is colocalized to the ER with several proteins that are involved in Alzheimer's disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues (1). Applications: Suitable for use in ELISA and Western Blot. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2088-59P |
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| Order / More Info | Caspase 12, IN, Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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