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| Product Name | Phosphoinositide 3-Kinase alpha, p110 alpha p85 alpha, Recombinant, Bovine (PI3K) |
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| Description | Purity ≥ 90% by SDS-PAGE. PI3K plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3K into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor It was also shown that PI3K mediated phosphorylation of the p85 adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3'-phosphorylated phosphoinositides. PI3K is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3K activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation. The PI3K catalytic and regulatory subunits are coexpressed in Sf9 insect cells. Phosphoinositide 3-kinases (PI3Ks) phosphorylate phosphatidylinositols (PIs) at their 3?-OH position generating lipid second messengers and thereby regulate numerous biological proce |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_174574/ NM_174575 |
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| Catalog # | P4073-31B |
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| Order / More Info | Phosphoinositide 3-Kinase alpha, p110 alpha p85 alpha, Recombinant, Bovine (PI3K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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